Allergome - A Database of Allergenic Molecules Search the Allergome database for allergenic molecules and sources Real Time Monitoring of IgE sensitization Real Time Monitoring of IgE sensitization Information on the Allergome web site and how to use it Links to Associations, Journals, Events, Projects, Manufacturers all related to the Allergome project Information on aims, scope, and mission of the Allergome project
About the Allergome Project
The allergenic molecule section (BLU section) of the Allergome Database is currently up-to-date. In this section as well as in the RED section some data from earlier publications ( < 1987) have not been processed yet. References cited in the GREEN section are up-to-date, but start with 2005.

This page has been updated on December 27, 2005

Allergome - A Database of Allergenic Molecules

Version 3.8

General Information
The Allergome e-Newsletter
Collaborative studies using the Allergome database
How to cite the Allergome database
The Allergome database has been cited in ...
History and Financial Supports of the Allergome project
The Allergome Team and Collaborators
Allergome Contacts



General Information

The Allergome web site has been designed to supply information on Allergenic Molecules (Allergens).
Identified molecules causing an IgE-mediated (allergic, atopic) disease (anaphylaxis, asthma, atopic dermatitis, conjunctivitis, rhinitis, urticaria) have been selected from international scientific journals and from web-based resources.
It also contains data on allergenic sources whether they have identified molecules or not.

Allergenic Molecules and sources are included in the Allergome Database independently from the sources (animals or plants) and their tissues (dander, fruit, pollen, seed, spores, venoms, whole bodies etc.), or the routes of exposure (contact, ingestion, inhalation, injection etc.).
A Monograph is dedicated to each Allergenic Molecule (BLUE monographs).

The Monograph is divided in three parts
  • The "General Information" page contains data for the identification of the Allergen and its relationship with other Allergens within the Allergome.
  • The "Native Form" page contains data on allergenicity of the allergen in its natural conformation.
  • The "Recombinant Form" page/s contains data on allergenicity of the allergen obtained by means of molecular biology techniques. "Recombinant Form" pages are named by the expression vector used to produce the recombinant molecule.
The Allergome is based on the literature published since the early sixties. The current base is 5800 selected papers (November 2004) and is continuously updated.
Before data entry, experienced reviewers select information from scientific papers.
Low-molecular weight compounds causing non-IgE-mediated allergic diseases (e.g. contact dermatitis, drug allergy), or molecules causing non-IgE immune mediated diseases (e.g. celiac disease) are not included. Any other substance causing pseudo-allergic reactions or intolerance (e.g. food intolerance) is excluded from the Allergome database.


Most of the Allergenic Molecules are officially named by the International Union of the Immunological Societies (IUIS) Allergen Nomenclature Sub-Committee and marked in the Allergome database. The updates list is available on the IUIS Allergen Nomenclature web site.
Criteria for the inclusion of a newly discovered allergenic molecule within the official list are available on international allergy journals and are recognized by the WHO.
All the Allergens and data available in the IUIS Allergen Nomenclature Sub-Committee web site are currently present in the Allergome Database.
The Allergome Database is searchable using the IUIS filter in order to have only officially recognized molecules as a search result.


On the basis of stringent immunological and allergological criteria, carefully characterized Allergens that are not listed in the IUIS Allergen Nomenclature are included in the Allergome Database. This further expands classified data available from the scientific literature.
The Allergome Database is searchable using the Allergenic Molecule filter. It includes all the identified and characterized Allergenic Molecules including those in the official IUIS Allergen Nomenclature list.


Allergenic sources without identified Allergenic Molecules are included in the Allergome Database (RED monographs).
This section mainly supplies references and little data for rare allergens and for allergenic sources whose allergenic components have never been identified and characterized. References dealing with allergenic sources are added to papers currently selected for Allergenic Molecules documentation. This completes the scenario of information on IgE-sensitizing compounds that are potentially harmful for allergic subjects.
To supply data (reagents, prevalence) on allergenic sources having identified allergens monographs have been added (GREEN monographs).
The search on allergenic sources (RED and GREEN monographs) is included in any search if neither the IUIS filter nor the Allergenic molecule filter are activated.


The Allergome Database is mainly addressed to people working in the Allergy and Immunology fields.
The structure and the data available in the Allergome Database are useful for clinicians to easily approach this rapidly expanding field of knowledge, and for basic researchers to reach information generally spread on several sources.
To avoid redundancy of information, external links are provided for data available on other free web sites.



The Allergome e-Newsletter

A monthly issue of the Allergome e-Newsletter is sent to all the subscribers and email addresses in the mailing list.
The Allergome e-Newsletter list the new and modified monographs during the last month period. You may access the monographs directly from the Allergome e-Newsletter by activating your browser and logging in the Allergome database.
News, tips, and info on events dealing with the Allergenic molecules are reported in the Allergome e-Newsletter.



Collaborative studies using the Allergome database

Data available from the Allergome database can be used for any study dealing with allergens. Collaborative studies between international research groups and the Allergome team are encouraged.
A collaborative study has been established with the Institute of Immunology Bern, Inselspital, Bern, Switzerland in 2003. The updated list of allergenic molecules has been used to further expand the results of previously published data (Stadler MB, Stadler BM. FASEB J 2003;17(9):1141-3). Results of the collaborative study are now displayed in the "Sequence Motifs" section of involved allergenic molecules. A presentation of the ongoing study has been given by Prof. BM Stadler (Autoimmunity and allergy: A bioinformatic approach) and published in the proceeding of the 25th Symposium of the Collegium Internationale Allergologicum, held in Bornholm, Denmark, 2004.


How to cite the Allergome database

The use of the Allergome database is free and any part of the data or original Allergome documents (images) may be used without permission. We greatly appreciate if the Allergome database as data source is cited. We suggest citing the date of data retrieval while using data from the Allergome database for further processing or for publications.
You may use either the Allergome URL (http://www.allergome.org/) or the following references:

Mari A, Riccioli D. The Allergome Web Site - A Database of Allergenic Molecules. Aim, Structure, and Data of a web-based resource.
60th Annual Meeting American Academy of Allergy, Asthma & Immunology. San Francisco, 2004. J Allergy Clin Immunol (2004); 113 (2,part 2), S301.

Mari A, Ronconi AM, Mari V. The Impact of Allergenic Molecules in Clinical Allergy. How far is the "Bench" from the "Bed"? A 35-year Retrospective Analysis of Papers from International Scientific Journals.
60th Annual Meeting American Academy of Allergy, Asthma & Immunology. San Francisco, 2004. J Allergy Clin Immunol (2004); 113 (2,part 2), S301.

Mari A, Mari V, Ronconi AM, Riccioli D. Use of the Allergome database to study the impact of allergenic molecules in clinical allergy: a 35-year retrospective analysis of papers from international scientific journals. XXIII Congress of the European Academy of Allergy and Clinical Immunology. Amsterdam, 2004. Congress Proceedings, p. 190.

Images supplied to the Allergome web site may be reproduced with permission.


The Allergome database has been cited in ...

2005
Bischoff S, Crowe SE. Gastroenterology 2005;128:1089-113
Bjorklund AK et al. Bioinformatics 2005;21:39-50
Breiteneder H, Mills C. Curr Opin Allergy Clin Immunol 2005;5:275-9
Chardin H, Peltre G. Expert Rev Proteomics 2005;2:757-65
Clement G et al. Protein Expr Purif 2005;44:110-20
Goodman RE et al. Int Arch Allergy Immunol 2005;137:153-66
Jenkins JA et al. J Allergy Clin.Immunol 2005;115:163-70
Linhart B, Valenta R. Curr Opin Immunol 2005;17:646-55
Law A et al. Curr.Proteomics 2005;2:147-64
Mari A. Int Arch Allergy Immunol 2005;138:88-96
Mari A, Ballmer-Weber BK, Vieths S. Curr Opin Allergy Clin Immunol 2005;5:267-73
Mohapatra SS et al. Curr Allergy Asthma Rep 2005;5:381-7
Thomas K et al. Toxicol.Sci 2005 Dec;88(2):307-10
Weichel M et al. Allergy 2005;61:128-35
Wopfner N et al. Int Arch Allergy Immunol 2005;138:337-46

2004
Breiteneder H, Radauer C. J Allergy Clin Immunol 2004;113:821-30
Bischoff S, Crowe SE. Curr Opin Gastroenterol 2004;20:156-61
Chapman MD. Allergen Nomenclature. In: Allergens and Allergen Immunotherapy, 3rd Edition, Editors: Lockey RF, Bukantz SC & Bousquet J, Marcel Dekker, 2004, pp51-64
Comstock SS et al. Clin Exp Allergy 2004;34:1583-90
Ferreira F et al. Allergy 2004;59:243-67
Gadermaier G et al. Curr Allergy Asthma Rep 2004;4:391-400
Malandain H. Allergy 2004;59:1011-2
Mothes N, Horak F, Valenta R. Int Arch Allergy Immunol 2004;135:357-73
Poulsen LK. Mol Nutr Food Res 2004;48:413-23
Rudeschko O et al. Allergy 2004;59:332-7
Schöll I, Jensen-Jarolim E. Int Arch Allergy Immunol 2004;135:247­61
Spiewak R. Allergologie 2004;10:402-7
van Ree R. Allergy 2004;59:571-4

2003
Brusic V et al. Allergy 2003;58:1093-100
Herman EM. J Exp Bot 2003;54:1317-9
Ivanciuc O et al. J Agric Food Chem 2003;51:4830-7

We gratefully thank the Authors.



History and Financial Supports of the Allergome project

The Allergome project is currently managed by "Allergy Data Laboratories s.c.", a non-for-profit company (ADL).

2002
The Allergome project started in 2002 as a self-funded project. The Allergome software version 1.0 is created.

2003
On February the Allergome database is available on line.
The Allergy Data Laboratories started to manage the Allergome project and to support it with internal funding.
Pharmacia Diagnostics decided to start to support the Allergome project with an unrestricted grant.
The friendly support of Francesco Redi allows the release of the Allergome software version 2.0 on May.

2004 
The Allergy Data Laboratories continues to manage and support the Allergome project. Pharmacia Diagnostics is supporting the Allergome project for the second year. Indoor Biotechnologies, Laboratorios Leti and Diagnostic Products Corporation start to support the Allergome project with unrestricted grants. The friendly support of Francesco Redi has been continued for the 2004 year. The current Allergome software (version 3.1) has been released in November 2004.

2005 
The Allergy Data Laboratories continues to manage and support the Allergome project. Pharmacia Diagnostics is supporting the Allergome project for the third year. Indoor Biotechnologies, Laboratorios Leti and Diagnostic Products Corporation start to support the Allergome project with unrestricted grants for the second year. Stallergenes, Allergopharma, VBC-Genomics, UCB Group and BIOMAY start to support the Allergome project. The friendly support of Francesco Redi has been continued for the current year.

The following institutions have started to support the Allergome project:
The University of Nebraska (USA) thru its FARRP project;
The University of Salzburg (Austria) thru its Priority Programme "BioScience and Health";
The Institute for Research in Biomedicine (Switzerland);
Sezione di Allergologia, Immunologia Clinica e Medicina del Lavoro, Università G. d'Annunzio di Chieti e Pescara, Italy.


The Allergome database is a free web site for users. Info and data available within the Allergome database are thought to be of general interest for the international scientific community. Any financial support to the Allergome project from public institutions, private individuals or companies is welcome.

If you need more information please do not hesitate to contact the Allergome administrator.

We greatly appreciate your feedback if you find any error in the allergenic molecule monograph data.

If you don't find what you expected in a search or you are aware of any identified allergen that is not in the Allergome database, please contact us.


The Allergome Team and Collaborators
Adriano Mari is a clinical allergist with expertise in basic immunology, immunochemistry and molecular biology, and information technology.
Virginia Mari takes care of the on line administrative work, the image collection, and the in-language translations.
Anna Maria Ronconi takes care of the on line administrative  work, the image collection and processing, and the ADL management.
Enrico Scala is a clinical allergist/immunologist with expertise in cellular immunology, and information technology

The in-language translations have been kindly revised by:
Ignacio Ansotegui (Spanish)
Luis Delgado (Portuguese)
Henri Malandain (French)
Stefan Wagner (German)

The Panservice team develops the original Allergome software.

Some of the images appearing in the Source monograph section have been supplied by  Laboratorios LetiAllergon and the Department of Entomology at North Carolina State University.



Allergome Contacts
General purposes and contacts with the Allergome team and collaborators: allergome@allergome.org

To contact the administrator: adriano.mari@allergome.org

For your valuable feedback: your.feedback@allergome.org

To place your link in the Links page: links@allergome.org

To contact the Allergy Data Laboratories: allergy.data.laboratories@allergome.org

Physical Address:

Dr. Adriano Mari
Allergy Data Laboratories s.c.
Via Malipiero 28
04100 Latina, Italy
tel +39 330860005
fax +39 0773 620787

Administrator

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